| Post Translational Modifications | Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1. Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK. Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation. Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes. |
| Function | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. |
| Protein Name | Phosphoinositide 3-Kinase Adapter Protein 1B-Cell Adapter For Phosphoinositide 3-KinaseB-Cell Phosphoinositide 3-Kinase Adapter Protein 1 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-6811558Reactome: R-HSA-983695 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane Protein |
| Alternative Protein Names | Phosphoinositide 3-Kinase Adapter Protein 1 proteinB-Cell Adapter For Phosphoinositide 3-Kinase proteinB-Cell Phosphoinositide 3-Kinase Adapter Protein 1 proteinPIK3AP1 proteinBCAP protein |
Information sourced from Uniprot.org
