• Human PIgR protein (Recombinant) (C-His) (STJP001402)

Human PIgR protein (Recombinant) (C-His) (STJP001402)

SKU:
STJP001402

£97.50 - £291.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/Mu g
Gene Symbol: PIGR
Gene ID: 5284
Uniprot ID: PIGR_HUMAN
Immunogen: Recombinant Human PIgR Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys19-Arg638) of human PIGR (Accession #NP_002635.2) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: KSPIFGPEEVNSVEGNSVSI TCYYPPTSVNRHTRKYWCRQ GARGGCITLISSEGYVSSKY AGRANLTNFPENGTFVVNIA QLSQDDSGRYKCGLGINSRG LSFDVSLEVSQGPGLLNDTK VYTVDLGRTVTINCPFKTEN AQKRKSLYKQIGLYPVLVID SSGYVNPNYTGRIRLDIQGT GQLLFSVVINQLRLSDAGQY LCQAGDDSNSNKKNADLQVL KPEPELVYEDLRGSVTFHC
Function Polymeric immunoglobulin receptor: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. Secretory component: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells.
Protein Name Polymeric Immunoglobulin Receptor
Pigr
Poly-Ig Receptor
Hepatocellular Carcinoma-Associated Protein Tb6 Cleaved Into - Secretory Component
Database Links Reactome: R-HSA-6798695
Cellular Localisation Polymeric Immunoglobulin Receptor: Cell Membrane
Single-Pass Type I Membrane Protein
Secretory Component: Secreted
Alternative Protein Names Polymeric Immunoglobulin Receptor protein
Pigr protein
Poly-Ig Receptor protein
Hepatocellular Carcinoma-Associated Protein Tb6 Cleaved Into - Secretory Component protein
PIGR protein

Information sourced from Uniprot.org

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