Human PI4KB protein (Recombinant) (N-His) (STJP009734)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PI4KB-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PI4KB |
| Gene ID | 5298 |
| Uniprot ID | PI4KB_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly547-Met816 |
Additional Info
| Function | Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking. May play an important role in the inner ear development. (Microbial infection) Plays an essential role in Aichi virus RNA replication. Recruited by ACBD3 at the viral replication sites. (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. |
| Protein Name | Phosphatidylinositol 4-Kinase BetaPi4k-BetaPi4kbetaPtdins 4-Kinase BetaNpikPi4k92Pi4kiii |
| Database Links | Reactome: R-HSA-1660514 |
| Cellular Localisation | Endomembrane SystemMitochondrion Outer MembranePeripheral Membrane ProteinRough Endoplasmic Reticulum MembraneGolgi ApparatusGolgi Apparatus MembraneCytoplasmPerinuclear RegionFound In The Outer Membrane Of Mitochondria And Membranes Of The Rough Endoplasmic ReticulumRecruited To The Golgi Complex By The Small Gtpase Arf To Stimulate The Synthesis Of Phosphatidylinositol 45-Bisphosphate (Pip2) On The Golgi ComplexRecruited To The Golgi Apparatus Membrane By Acbd3Gga2 Is Also Involved In The Recruitment |
| Alternative Protein Names | Phosphatidylinositol 4-Kinase Beta proteinPi4k-Beta proteinPi4kbeta proteinPtdins 4-Kinase Beta proteinNpik proteinPi4k92 proteinPi4kiii proteinPI4KB proteinPIK4CB protein |
Information sourced from Uniprot.org