Human PI4KB protein (Recombinant) (N-His) (STJP009734)

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STJP009734
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PI4KB-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PI4KB
Gene ID: 5298
Uniprot ID: PI4KB_HUMAN
Immunogen Region: Gly547-Met816
Immunogen: Homo sapiens (Human)
Function Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking. May play an important role in the inner ear development. (Microbial infection) Plays an essential role in Aichi virus RNA replication. Recruited by ACBD3 at the viral replication sites. (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.
Protein Name Phosphatidylinositol 4-Kinase Beta
Pi4k-Beta
Pi4kbeta
Ptdins 4-Kinase Beta
Npik
Pi4k92
Pi4kiii
Database Links Reactome: R-HSA-1660514
Cellular Localisation Endomembrane System
Mitochondrion Outer Membrane
Peripheral Membrane Protein
Rough Endoplasmic Reticulum Membrane
Golgi Apparatus
Golgi Apparatus Membrane
Cytoplasm
Perinuclear Region
Found In The Outer Membrane Of Mitochondria And Membranes Of The Rough Endoplasmic Reticulum
Recruited To The Golgi Complex By The Small Gtpase Arf To Stimulate The Synthesis Of Phosphatidylinositol 4
5-Bisphosphate (Pip2) On The Golgi Complex
Recruited To The Golgi Apparatus Membrane By Acbd3
Gga2 Is Also Involved In The Recruitment
Alternative Protein Names Phosphatidylinositol 4-Kinase Beta protein
Pi4k-Beta protein
Pi4kbeta protein
Ptdins 4-Kinase Beta protein
Npik protein
Pi4k92 protein
Pi4kiii protein
PI4KB protein
PIK4CB protein

Information sourced from Uniprot.org