| Tissue Specificity | Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes. |
| Post Translational Modifications | N- and O-glycosylated. Both N-glycosylation recognition sites are almost quantitatively occupied by N-glycans of the biantennary complex type, with a considerable proportion of structures bearing a bisecting GlcNAc. N-glycan at Asn-78: dHex1Hex5HexNAc4. Agalacto structure as well as sialylated and nonsialylated oligosaccharides bearing alpha2-3- and/or alpha2-6-linked NeuNAc are present. |
| Function | Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR. |
| Protein Name | Prostaglandin-H2 D-IsomeraseBeta-Trace ProteinCerebrin-28Glutathione-Independent Pgd SynthaseLipocalin-Type Prostaglandin-D SynthaseL-PgdsProstaglandin-D2 SynthasePgd2 SynthasePgdsPgds2 |
| Database Links | Reactome: R-HSA-2162123Reactome: R-HSA-9690406 |
| Cellular Localisation | Rough Endoplasmic ReticulumNucleus MembraneGolgi ApparatusCytoplasmPerinuclear RegionSecretedDetected On Rough Endoplasmic Reticulum Of Arachnoid And Menigioma CellsLocalized To The Nuclear EnvelopeSecretory Vesicles And Spherical Cytoplasmic Structures In Arachnoid Trabecular CellsAnd To Circular Cytoplasmic Structures In Meningeal Macrophages And Perivascular Microglial CellsIn OligodendrocytesLocalized To The Rough Endoplasmic Reticulum And Nuclear EnvelopeIn Retinal Pigment Epithelial CellsLocalized To Distinct Cytoplasmic Domains Including The Perinuclear RegionAlso Secreted |
| Alternative Protein Names | Prostaglandin-H2 D-Isomerase proteinBeta-Trace Protein proteinCerebrin-28 proteinGlutathione-Independent Pgd Synthase proteinLipocalin-Type Prostaglandin-D Synthase proteinL-Pgds proteinProstaglandin-D2 Synthase proteinPgd2 Synthase proteinPgds proteinPgds2 proteinPTGDS proteinPDS protein |
Information sourced from Uniprot.org
