Human Peroxiredoxin 5/PRDX5 protein (Recombinant) (No-Tag) (STJP019391)

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STJP019391
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Short Description :Recombinant-Human Peroxiredoxin 5/PRDX5-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Applications:SDS-PAGE/Enzyme Activity
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM HEPES buffer (pH 7.4)
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin:< 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity:Specific activity is >9, 000pmol/min/ug. Enzymatic activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25C for 1minute.
Gene Symbol:PRDX5
Gene ID:25824
Uniprot ID:PRDX5_HUMAN
Accession Number:NP_036226
Immunogen:Human
Immunogen Region:53-214aa
Immunogen Sequence:MAPIKVGDAI PAVEVFEGEP GNKVNLAELF KGKKGVLFGV PGAFTPGCSK THLPGFVEQA EALKAKGVQV VACLSVNDAF VTGEWGRAHKAEGKVRLLAD PTGAFGKETD LLLDDSLVSI FGNRRLKRFS MVVQDGIVKA LNVEPDGTGL TCSLAPNIIS QL
Tissue Specificity Widely expressed.
Post Translational Modifications S-palmitoylated. Palmitoylation occurs on the active site, inhibiting its reactivity.therefore PRDX5 palmitoylation status determines its antioxidant capacity. Isoform Mitochondrial: S-palmitoylated. Depalmitoylated by ABHD10.
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Protein Name Peroxiredoxin-5 - Mitochondrial
Alu Corepressor 1
Antioxidant Enzyme B166
Aoeb166
Liver Tissue 2d-Page Spot 71b
Plp
Peroxiredoxin V
Prx-V
Peroxisomal Antioxidant Enzyme
Tpx Type Vi
Thioredoxin Peroxidase Pmp20
Thioredoxin-Dependent Peroxiredoxin 5
Database Links Reactome: R-HSA-3299685
Reactome: R-HSA-5628897 P30044-2
Cellular Localisation Isoform Mitochondrial: Mitochondrion
Isoform Cytoplasmic+Peroxisomal: Cytoplasm
Peroxisome Matrix
Imported Into Peroxisomes Via Peroxisomal Targeting Signal 1 Receptor Pex5
Alternative Protein Names Peroxiredoxin-5 - Mitochondrial protein
Alu Corepressor 1 protein
Antioxidant Enzyme B166 protein
Aoeb166 protein
Liver Tissue 2d-Page Spot 71b protein
Plp protein
Peroxiredoxin V protein
Prx-V protein
Peroxisomal Antioxidant Enzyme protein
Tpx Type Vi protein
Thioredoxin Peroxidase Pmp20 protein
Thioredoxin-Dependent Peroxiredoxin 5 protein
PRDX5 protein
ACR1 protein
SBBI10 protein

Information sourced from Uniprot.org

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