Human Peroxiredoxin 4/PRDX4 protein (Recombinant) (His-Tag) (STJP016654)

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STJP016654
£125.50 - £649.50
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Host: E.coli
Applications: SDS-PAGE/Enzyme Activity
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Peroxiredoxin 4/PRDX4-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Specific activity is >2, 000pmol/min/ug. Enzymatic activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25C for 1minute.
Gene Symbol: PRDX4
Gene ID: 10549
Uniprot ID: PRDX4_HUMAN
Immunogen Region: 38-271aa
Accession Number: NP_006397
Immunogen: Human
Immunogen Sequence: MWETEERPRT REEECHFYAG GQVYPGEASR VSVADHSLHL SKAKISKPAP YWEGTAVIDG EFKELKLTDY RGKYLVFFFY PLDFTFVCPT EIIAFGDRLE EFRSINTEVV ACSVDSQFTH LAWINTPRRQ GGLGPIRIPL LSDLTHQISK DYGVYLEDSG HTLRGLFIID DKGILRQITL NDLPVGRSVD ETLRLVQAFQ YTDKHG
Post Translational Modifications The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
Protein Name Peroxiredoxin-4
Antioxidant Enzyme Aoe372
Aoe37-2
Peroxiredoxin Iv
Prx-Iv
Thioredoxin Peroxidase Ao372
Thioredoxin-Dependent Peroxide Reductase A0372
Thioredoxin-Dependent Peroxiredoxin 4
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cytoplasm
Endoplasmic Reticulum
Cotranslationally Translocated To And Retained Within The Endoplasmic Reticulum
A Small Fraction Of The Protein Is Cytoplasmic
Alternative Protein Names Peroxiredoxin-4 protein
Antioxidant Enzyme Aoe372 protein
Aoe37-2 protein
Peroxiredoxin Iv protein
Prx-Iv protein
Thioredoxin Peroxidase Ao372 protein
Thioredoxin-Dependent Peroxide Reductase A0372 protein
Thioredoxin-Dependent Peroxiredoxin 4 protein
PRDX4 protein

Information sourced from Uniprot.org

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