Human PEF1 protein (Recombinant) (His-Tag) (STJP017043)

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STJP017043
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Short Description :Recombinant-Human PEF1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.25 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50% Glycerol, 0.2M NaCl
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:PEF1
Gene ID:553115
Uniprot ID:PEF1_HUMAN
Accession Number:NP_036524
Immunogen:Human
Immunogen Region:1-284aa
Immunogen Sequence:MASY PYRQGCPGAA GQAPGAPPGS YYPGPPNSGG QYGSGLPPGG GYGGPAPGGP YGPPAGGGPY GHPNPGMFPS GTPGGPYGGA APGGPYGQPP PSSYGAQQPG LYGQGGAPPN VDPEAYSWFQ SVDSDHSGYI SMKELKQALV NCNWSSFNDE TCLMMINMFD KTKSGRIDVY GFSALWKFIQ QWKNLF
Post Translational Modifications Ubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex.
Function Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium. Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6. Also acts as a negative regulator of ER-Golgi transport.possibly by inhibiting interaction between PDCD6 and SEC31.
Protein Name Peflin
Pef Protein With A Long N-Terminal Hydrophobic Domain
Penta-Ef Hand Domain-Containing Protein 1
Database Links
Cellular Localisation Cytoplasm
Endoplasmic Reticulum
Membrane
Peripheral Membrane Protein
Cytoplasmic Vesicle
Copii-Coated Vesicle Membrane
Membrane-Associated In The Presence Of Ca(2+)
Localizes To Endoplasmic Reticulum Exit Site (Eres)
Alternative Protein Names Peflin protein
Pef Protein With A Long N-Terminal Hydrophobic Domain protein
Penta-Ef Hand Domain-Containing Protein 1 protein
PEF1 protein
ABP32 protein
UNQ1845 protein
PRO3573 protein

Information sourced from Uniprot.org

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