| Post Translational Modifications | Phosphorylated on tyrosine residue(s). Can be dephosphorylated by PTPN13. |
| Function | Isoform 1: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons. Isoform 2: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. |
| Protein Name | Pdz And Lim Domain Protein 4Lim Protein RilReversion-Induced Lim Protein |
| Database Links | |
| Cellular Localisation | Isoform 1: CytoplasmCytoskeletonNucleusCytoplasmPerinuclear RegionCell ProjectionLamellipodiumDendritic SpineEarly Endosome MembranePeripheral Membrane ProteinCytoplasmic SideRecycling Endosome MembraneSynapseSynaptosomeLocalizes To Actin Stress Fibers In Nonmuscle CellsColocalizes With Gria1 In Early EndosomesEnriched In Numerous But Not All Spine-Like Structures Along Dendritic BranchesColocalizes With Actin And Enriched At Sites Containing Larger Amounts Of Actin And Alpha-ActininTargeted Efficiently To Spines Via Its Pdz Domain-Mediated Interaction With The Alpha-Actinin/Actin Cytoskeletal ComplexLocalizes To Synaptosomes In BrainColocalizes With F-ActinColocalizes With Trip6 At Cell-Cell Contacts And LamellipodiaIn The CytoplasmDisplays A Fibrillar Pattern With Characteristic Thick Fibers And Occasional ClustersColocalizes With The Actin Stress FibersOxidative Stress Induces Redistribution From Cytoskeleton To CytosolColocalizes With Src At The Perinuclear RegionBut Not At Focal AdhesionsIsoform 2: CytoplasmStains More Diffusely In The Cytoplasm With Thin Fibers Forming A Dense Mesh-Like Pattern |
| Alternative Protein Names | Pdz And Lim Domain Protein 4 proteinLim Protein Ril proteinReversion-Induced Lim Protein proteinPDLIM4 proteinRIL protein |
Information sourced from Uniprot.org
