Human PDIA6 protein (Recombinant) (C-His) (STJP013476)

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STJP013476-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PDIA6-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: PDIA6
Gene ID: 10130
Uniprot ID: PDIA6_HUMAN
Immunogen Region: Leu20-Leu440
Immunogen: Homo sapiens (Human)
Function May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
Protein Name Protein Disulfide-Isomerase A6
Endoplasmic Reticulum Protein 5
Er Protein 5
Erp5
Protein Disulfide Isomerase P5
Thioredoxin Domain-Containing Protein 7
Database Links Reactome: R-HSA-381038
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Cellular Localisation Endoplasmic Reticulum Lumen
Cell Membrane
Melanosome
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Alternative Protein Names Protein Disulfide-Isomerase A6 protein
Endoplasmic Reticulum Protein 5 protein
Er Protein 5 protein
Erp5 protein
Protein Disulfide Isomerase P5 protein
Thioredoxin Domain-Containing Protein 7 protein
PDIA6 protein
ERP5 protein
P5 protein
TXNDC7 protein

Information sourced from Uniprot.org