| Post Translational Modifications | Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG. Sumoylated with SUMO1. N-glycosylated. |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. |
| Protein Name | Platelet-Derived Growth Factor CPdgf-CFalloteinSpinal Cord-Derived Growth FactorScdgfVegf-E Cleaved Into - Platelet-Derived Growth Factor C - Latent FormPdgfc Latent Form - Platelet-Derived Growth Factor C - Receptor-Binding FormPdgfc Receptor-Binding Form |
| Database Links | Reactome: R-HSA-186797 Q9NRA1-1 |
| Cellular Localisation | CytoplasmCytosolSecretedNucleusCytoplasmic GranuleCell MembraneSumoylated Form Is Predominant In The NucleusStored In Alpha Granules In Platelets |
| Alternative Protein Names | Platelet-Derived Growth Factor C proteinPdgf-C proteinFallotein proteinSpinal Cord-Derived Growth Factor proteinScdgf proteinVegf-E Cleaved Into - Platelet-Derived Growth Factor C - Latent Form proteinPdgfc Latent Form - Platelet-Derived Growth Factor C - Receptor-Binding Form proteinPdgfc Receptor-Binding Form proteinPDGFC proteinSCDGF proteinUNQ174 proteinPRO200 protein |
Information sourced from Uniprot.org
