| Short Description : | Recombinant-Active-Human PCSK1-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its ability to cleave the fluorogenic peptide substrate pERTKR-AMC. The specific activity is >30 pmol/min/µg, as measured under the described conditions. |
| Gene Symbol: | PCSK1 |
| Gene ID: | 5122 |
| Uniprot ID: | NEC1_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Ser111-Arg617 |
| Function | Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP. |
| Protein Name | Neuroendocrine Convertase 1Nec 1Prohormone Convertase 1Proprotein Convertase 1Pc1 |
| Database Links | Reactome: R-HSA-209952Reactome: R-HSA-264876Reactome: R-HSA-381771Reactome: R-HSA-400511Reactome: R-HSA-422085 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleLocalized In The Secretion Granules |
| Alternative Protein Names | Neuroendocrine Convertase 1 proteinNec 1 proteinProhormone Convertase 1 proteinProprotein Convertase 1 proteinPc1 proteinPCSK1 proteinNEC1 protein |
Information sourced from Uniprot.org
