Human PCBP1 protein (Recombinant) (His-Tag) (STJP018417)

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STJP018417
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PCBP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: PCBP1
Gene ID: 5093
Uniprot ID: PCBP1_HUMAN
Immunogen Region: 1-163aa
Accession Number: NP_006187
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSMDAGVTE SGLNVTLTIR LLMHGKEVGS IIGKKGESVK RIREESGARI NISEGNCPER IITLTGPTNA IFKAFAMIID KLEEDINSSM TNSTAASRPP VTLRLVVPAT QCGSLIGKGG CKIKEIREST GAQVQVAGDM LPNSTERAIT IAGVPQSVTE CVKQIC
Tissue Specificity Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands.
Post Translational Modifications Phosphorylated.lowers poly(rC)-binding activity.
Function Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing. (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD.
Protein Name Poly(Rc-Binding Protein 1
Alpha-Cp1
Heterogeneous Nuclear Ribonucleoprotein E1
Hnrnp E1
Nucleic Acid-Binding Protein Sub2.3
Database Links Reactome: R-HSA-72163
Reactome: R-HSA-72203
Cellular Localisation Nucleus
Cytoplasm
Loosely Bound In The Nucleus
May Shuttle Between The Nucleus And The Cytoplasm
Alternative Protein Names Poly(Rc-Binding Protein 1 protein
Alpha-Cp1 protein
Heterogeneous Nuclear Ribonucleoprotein E1 protein
Hnrnp E1 protein
Nucleic Acid-Binding Protein Sub2.3 protein
PCBP1 protein

Information sourced from Uniprot.org

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