Human PARVA protein (Recombinant) (C-His) (STJP014750)

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STJP014750-100
£575.50
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Host: E.coli
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PARVA-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Supplied as a 0.22 Mu m filtered solution in 50mM Tris-HCl, 150mM NaCl, 40% Glycerol, pH 7.4.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: PARVA
Gene ID: 55742
Uniprot ID: PARVA_HUMAN
Immunogen Region: Met1-Glu372
Immunogen: Homo sapiens (Human)
Function Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration.
Protein Name Alpha-Parvin
Actopaxin
Ch-Ilkbp
Calponin-Like Integrin-Linked Kinase-Binding Protein
Matrix-Remodeling-Associated Protein 2
Database Links Reactome: R-HSA-446343
Reactome: R-HSA-446353
Reactome: R-HSA-446388
Cellular Localisation Cell Junction
Focal Adhesion
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasm
Cytoskeleton
Myofibril
Sarcomere
Z Line
Alternative Protein Names Alpha-Parvin protein
Actopaxin protein
Ch-Ilkbp protein
Calponin-Like Integrin-Linked Kinase-Binding Protein protein
Matrix-Remodeling-Associated Protein 2 protein
PARVA protein
MXRA2 protein

Information sourced from Uniprot.org