Human PARN protein (Recombinant) (N-GST) (STJP003431)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PARN-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PARN |
| Gene ID | 5073 |
| Uniprot ID | PARN_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys178-Asp245 |
Additional Info
| Post Translational Modifications | Phosphorylation by MAPKAPK2, preventing GADD45A mRNA degradation after genotoxic stress. |
| Function | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability. |
| Protein Name | Poly(A-Specific Ribonuclease ParnDeadenylating NucleaseDeadenylation NucleasePolyadenylate-Specific Ribonuclease |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-429947Reactome: R-HSA-450604 |
| Cellular Localisation | NucleusCytoplasmNucleolusSome Nuclear Fraction Is Nucleolar |
| Alternative Protein Names | Poly(A-Specific Ribonuclease Parn proteinDeadenylating Nuclease proteinDeadenylation Nuclease proteinPolyadenylate-Specific Ribonuclease proteinPARN proteinDAN protein |
Information sourced from Uniprot.org