Human PARD6B protein (Recombinant) (His-Tag) (STJP017947)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PARD6B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2M urea, 20% Glycerol, 0.2M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PARD6B |
| Gene ID | 84612 |
| Uniprot ID | PAR6B_HUMAN |
| Accession Number | NP_115910 |
| Immunogen | Human |
| Immunogen Region | 1-372aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMNRSHRH GAGSGCLGTM EVKSKFGAEF RRFSLERSKP GKFEEFYGLL QHVHKIPNVD VLVGYADIHG DLLPINNDDN YHKAVSTANP LLRIFIQKKE EADYSAFGTD TLIKKKNVLT NVLRPDNHRK KPHIVISMPQ DFRPVSSIID VDILPETHRR VRLYKYGTEK PLGFYIRDGS SVRVTPHGLE KVPGIFISRL VPGGLAQS |
Additional Info
| Tissue Specificity | Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues. |
| Function | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. |
| Protein Name | Partitioning Defective 6 Homolog BetaPar-6 BetaPar-6b |
| Database Links | Reactome: R-HSA-420029Reactome: R-HSA-9013424 |
| Cellular Localisation | CytoplasmCell MembraneCell JunctionTight Junction |
| Alternative Protein Names | Partitioning Defective 6 Homolog Beta proteinPar-6 Beta proteinPar-6b proteinPARD6B proteinPAR6B protein |
Information sourced from Uniprot.org