| Tissue Specificity | Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid. |
| Post Translational Modifications | The Cys-30/Cys-54 disulfide bond is required for activity. |
| Function | Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. |
| Protein Name | C-C Motif Chemokine 18Alternative Macrophage Activation-Associated Cc Chemokine 1Amac-1Cc Chemokine ParcDendritic Cell Chemokine 1Dc-Ck1Macrophage Inflammatory Protein 4Mip-4Pulmonary And Activation-Regulated ChemokineSmall-Inducible Cytokine A18 Cleaved Into - Ccl18(1-68 - Ccl18(3-69 - Ccl18(4-69 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | C-C Motif Chemokine 18 ELISA kitAlternative Macrophage Activation-Associated Cc Chemokine 1 ELISA kitAmac-1 ELISA kitCc Chemokine Parc ELISA kitDendritic Cell Chemokine 1 ELISA kitDc-Ck1 ELISA kitMacrophage Inflammatory Protein 4 ELISA kitMip-4 ELISA kitPulmonary And Activation-Regulated Chemokine ELISA kitSmall-Inducible Cytokine A18 Cleaved Into - Ccl18(1-68 - Ccl18(3-69 - Ccl18(4-69 ELISA kitCCL18 ELISA kitAMAC1 ELISA kitDCCK1 ELISA kitMIP4 ELISA kitPARC ELISA kitSCYA18 ELISA kit |
| output | |
Information sourced from Uniprot.org
