Human PAPPA protein (Recombinant) (N-His) (STJP005301)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PAPPA-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PAPPA |
| Gene ID | 5069 |
| Uniprot ID | PAPP1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu317-Pro532 |
Additional Info
| Post Translational Modifications | There appear to be no free sulfhydryl groups. |
| Function | Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. |
| Protein Name | Pappalysin-1Insulin-Like Growth Factor-Dependent Igf-Binding Protein 4 ProteaseIgf-Dependent Igfbp-4 ProteaseIgfbp-4asePregnancy-Associated Plasma Protein APapp-A |
| Database Links | Reactome: R-HSA-381426 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Pappalysin-1 proteinInsulin-Like Growth Factor-Dependent Igf-Binding Protein 4 Protease proteinIgf-Dependent Igfbp-4 Protease proteinIgfbp-4ase proteinPregnancy-Associated Plasma Protein A proteinPapp-A proteinPAPPA protein |
Information sourced from Uniprot.org