Human PAI1 (Plasminogen Activator Inhibitor 1) Antibody Pair (STJAP00186)
General Information
| Short Description | This PAI1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Goat/Goat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal/Polyclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | SERPINE1 |
| Gene ID | 5054 |
| Uniprot ID | PAI1_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human PAI1 protein.Detection Immunogen: Recombinant Human PAI1 protein. |
Additional Info
| Post Translational Modifications | Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond. |
| Function | Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis. |
| Protein Name | Plasminogen Activator Inhibitor 1PaiPai-1Endothelial Plasminogen Activator InhibitorSerpin E1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1368108Reactome: R-HSA-2173796Reactome: R-HSA-3000178Reactome: R-HSA-75205Reactome: R-HSA-9926550 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Plasminogen Activator Inhibitor 1 antibody pairPai antibody pairPai-1 antibody pairEndothelial Plasminogen Activator Inhibitor antibody pairSerpin E1 antibody pairSERPINE1 antibody pairPAI1 antibody pairPLANH1 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human PAI1 (Plasminogen Activator Inhibitor 1) Antibody Pair (STJAP00186)
This antibody pair is designed to detect human PAI1 (Plasminogen Activator Inhibitor 1), corresponding to UniProt entry P05121. Reactivity is confirmed for human samples only.
The capture antibody is supplied unconjugated at 0.5 mg/mL, while the detection antibody is biotin-conjugated at 0.5 mg/mL. Both are formulated in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.4.
This pair has been validated for use in ELISA. No other assay formats are listed in the product specifications.
Both the capture and detection antibodies were raised in goat against recombinant human PAI1 protein. Both are polyclonal and have been purified by antigen affinity purification.
Both components should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain product integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.