Human P75 Neurogranin (P75 Neurogranin) Antibody Pair (STJAP00807)
General Information
| Short Description | This P75 Neurogranin antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R12-8Y-5/R35-2F-4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | NRGN |
| Gene ID | 4900 |
| Uniprot ID | NEUG_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease. |
| Post Translational Modifications | Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions. |
| Function | Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. |
| Protein Name | NeurograninNgRc3 Cleaved Into - Neug(55-78 |
| Database Links | Reactome: R-HSA-9620244 |
| Cellular Localisation | |
| Alternative Antibody Pair Names | Neurogranin antibody pairNg antibody pairRc3 Cleaved Into - Neug(55-78 antibody pairNRGN antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human P75 Neurogranin (P75 Neurogranin) Antibody Pair (STJAP00807)
This antibody pair is designed to detect human P75 Neurogranin, corresponding to UniProt entry Q92686. Reactivity has been confirmed for human samples only.
This antibody pair has been validated for use in ELISA. It is intended for sandwich ELISA development, with one antibody serving as the capture and the other as the detection component.
Both antibodies are rabbit monoclonal IgGs supplied unconjugated at 1 mg/mL, formulated in 0.01M PBS at pH 7.2. Clone IDs are R12-8Y-5 and R35-2F-4, and both are affinity purified.
Optimal working concentrations are not pre-defined for this pair and must be determined empirically by the end user during assay development.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and keep at -20°C. Repeated freeze/thaw cycles should be avoided to preserve activity.
Both antibodies were raised in rabbit against a recombinant protein immunogen corresponding to human P75 Neurogranin. No additional immunogen region information is specified for this product.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.