| Post Translational Modifications | Phosphorylation results in its inactivation. ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel. Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface. |
| Function | Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells. |
| Protein Name | P2x Purinoceptor 7P2x7Atp ReceptorP2z ReceptorPurinergic Receptor |
| Database Links | Reactome: R-HSA-139853Reactome: R-HSA-418346Reactome: R-HSA-844456Reactome: R-HSA-9660826 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | P2x Purinoceptor 7 proteinP2x7 proteinAtp Receptor proteinP2z Receptor proteinPurinergic Receptor proteinP2RX7 protein |
Information sourced from Uniprot.org
