SDS-PAGE gel of recombinant human OXSR1 protein under reducing conditions Coomassie blue stain

Human OXSR1 protein (Recombinant) (His-Tag) (STJP018941)

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STJP018941
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Short Description :Recombinant-Human OXSR1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in phosphate-Buffered Saline (pH 7.4) containing 30% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:OXSR1
Gene ID:9943
Uniprot ID:OXSR1_HUMAN
Accession Number:NP_005100
Immunogen:Human
Immunogen Region:1-527aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSEDSSA LPWSINRDDY ELQEVIGSGA TAVVQAAYCA PKKEKVAIKR INLEKCQTSM DELLKEIQAM SQCHHPNIVS YYTSFVVKDE LWLVMKLLSG GSVLDIIKHI VAKGEHKSGV LDESTIATIL REVLEGLEYL HKNGQIHRDV KAGNILLGED GSVQIADFGV SAFLATGGDI TRNKVRKTFV GTPCWMAPEV MEQVRGYD
Tissue Specificity Ubiquitously expressed in all tissue examined.
Post Translational Modifications Phosphorylation at Thr-185 by WNK kinases (WNK1, WNK2, WNK3 or WNK4) is required for activation. Autophosphorylated.promoting its activity.
Function Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure. Specifically recognizes and binds proteins with a RFXV motif. Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity. Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases. Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx.simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux. Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4. Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1. Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation. Phosphorylates RELL1, RELL2 and RELT. Phosphorylates PAK1. Phosphorylates PLSCR1 in the presence of RELT.
Protein Name Serine/Threonine-Protein Kinase Osr1
Oxidative Stress-Responsive 1 Protein
Database Links
Cellular Localisation Cytoplasm
Alternative Protein Names Serine/Threonine-Protein Kinase Osr1 protein
Oxidative Stress-Responsive 1 Protein protein
OXSR1 protein
KIAA1101 protein
OSR1 protein

Information sourced from Uniprot.org

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