Human OTUD3 protein (Recombinant) (N-His) (STJP015965)

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STJP015965
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human OTUD3-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: Please contact us for further information.
Gene Symbol: OTUD3
Gene ID: 23252
Uniprot ID: OTUD3_HUMAN
Immunogen Region: Gly46-Lys220
Immunogen: Homo sapiens (Human)
Function Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination.
Protein Name Otu Domain-Containing Protein 3
Database Links Reactome: R-HSA-5689896
Reactome: R-HSA-8948751
Cellular Localisation Cytoplasm
Nucleus
Glucose Or Fatty Acid Promote Nuclear Translocation Upon Acetylation
Alternative Protein Names Otu Domain-Containing Protein 3 protein
OTUD3 protein
KIAA0459 protein

Information sourced from Uniprot.org

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