Tissue Specificity | Restricted to bone-derived cell. |
Post Translational Modifications | Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours. Propionylated. Depropionylation at Lys-371 by SIRT7 activates transcription factor activity and positively regulates bone formation by osteoblasts. |
Function | Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences. |
Protein Name | Transcription Factor Sp7Zinc Finger Protein Osterix |
Database Links | Reactome: R-HSA-8940973 |
Cellular Localisation | Nucleus |
Alternative ELISA Names | Transcription Factor Sp7 ELISA kitZinc Finger Protein Osterix ELISA kitSP7 ELISA kitOSX ELISA kit |
output | |
Information sourced from Uniprot.org