• Human Osteonectin/SPARC protein (Recombinant) (C-His) (STJP000988)

Human Osteonectin/SPARC protein (Recombinant) (C-His) (STJP000988)

SKU:
STJP000988

£148.50 - £224.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Gene Symbol: SPARC
Gene ID: 6678
Uniprot ID: SPRC_HUMAN
Immunogen: Recombinant Human Osteonectin/SPARC Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala18-Ile303) of human Osteonectin/SPARC (Accession #NP_003109.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: APQQEALPDETEVVEETVAE VTEVSVGANPVQVEVGEFDD GAEETEEEVVAENPCQNHHC KHGKVCELDENNTPMCVCQD PTSCPAPIGEFEKVCSNDNK TFDSSCHFFATKCTLEGTKK GHKLHLDYIGPCKYIPPCLD SELTEFPLRMRDWLKNVLVT LYERDEDNNLLTEKQKLRVK KIHENEKRLEAGDHPVELLA RDFEKNYNMYIFPVHWQFGQ LDQHPIDGYLSHTELAPLR
Function Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites.an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Protein Name Sparc
Basement-Membrane Protein 40
Bm-40
Osteonectin
On
Secreted Protein Acidic And Rich In Cysteine
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-1251985
Reactome: R-HSA-3000178
Reactome: R-HSA-3000497
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Basement Membrane
In Or Around The Basement Membrane
Alternative Protein Names Sparc protein
Basement-Membrane Protein 40 protein
Bm-40 protein
Osteonectin protein
On protein
Secreted Protein Acidic And Rich In Cysteine protein
SPARC protein
ON protein

Information sourced from Uniprot.org

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