| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | OSMR |
| Gene ID: | 9180 |
| Uniprot ID: | OSMR_HUMAN |
| Immunogen: | Recombinant Human OSMR/IL-31RB Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Glu28-Ser739) of human OSMR (Accession #NP_003990) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | ERLPLTPVSLKVSTNSTRQS LHLQWTVHNLPYHQELKMVF QIQISRIETSNVIWVGNYST TVKWNQVLHWSWESELPLEC ATHFVRIKSLVDDAKFPEPN FWSNWSSWEEVSVQDSTGQD ILFVFPKDKLVEEGTNVTIC YVSRNIQNNVSCYLEGKQIH GEQLDPHVTAFNLNSVPFIR NKGTNIYCEASQGNVSEGMK GIVLFVSKVLEEPKDFSCET EDFKTLHCTWDPGTDTALG |
| Tissue Specificity | Expressed in keratinocytes (at protein level). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells. |
| Function | Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. |
| Protein Name | Oncostatin-M-Specific Receptor Subunit BetaInterleukin-31 Receptor Subunit BetaIl-31 Receptor Subunit BetaIl-31r Subunit BetaIl-31r-BetaIl-31rb |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Oncostatin-M-Specific Receptor Subunit Beta proteinInterleukin-31 Receptor Subunit Beta proteinIl-31 Receptor Subunit Beta proteinIl-31r Subunit Beta proteinIl-31r-Beta proteinIl-31rb proteinOSMR proteinOSMRB protein |
Information sourced from Uniprot.org
