Human Opticin protein (Recombinant) (His-Tag) (STJP019004)

Name: Human Opticin protein (Recombinant) (His-Tag) (STJP019004)
SKU: STJP019004
Availability: InStock

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SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP019004

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Short Description	Recombinant-Human Opticin-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE/Denatured
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	OPTC
Gene ID	26254
Uniprot ID	OPT_HUMAN
Accession Number	NP_055174
Immunogen	Human
Immunogen Region	20-332aa
Immunogen Sequence	ASLPRKE RKRREEQMPR EGDSFEVLPL RNDVLNPDNY GEVIDLSNYE ELTDYGDQLP EVKVTSLAPA TSISPAKSTT APGTPSSNPT MTRPTTAGLL LSSQPNHGLP TCLVCVCLGS SVYCDDIDLE DIPPLPRRTA YLYARFNRIS RIRAEDFKGL TKLKRIDLSN NLISSIDNDA FRLLHALQDL ILPENQLEAL PVLPSG

Tissue Specificity	Expressed in cartilage and synovial membranes (at protein level). Expressed in the retina, iris, ligament, skin and fetal liver (at protein level). Expressed in the retinal pigment epithelium (at protein level). Expressed in synovial fibroblasts and subchondral bone osteoblasts.
Post Translational Modifications	O-glycosylated. Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5. Proteolytically cleaved by MMP13. The degradation of OPTC by proteases may contribute to osteoarthritis pathophysiology. Sulfated on tyrosine residues.
Function	Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization. Binds collagen fibrils. May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily.
Protein Name	Opticin Oculoglycan
Database Links	Reactome: R-HSA-1474228
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Protein Names	Opticin protein Oculoglycan protein OPTC protein OPT protein

Information sourced from Uniprot.org