SDS-PAGE gel showing recombinant human Oncostatin M OSM protein under reducing conditions stained with Coomassie blue

Human Oncostatin M/OSM protein (Recombinant) (His-Tag) (STJP017258)

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STJP017258
£134.50 - £738.50
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Short Description :Recombinant-Human Oncostatin M/OSM-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin:< 1 EU per 1ug of protein (determined by LAL method)
Gene Symbol:OSM
Gene ID:5008
Uniprot ID:ONCM_HUMAN
Accession Number:NP_065391
Immunogen:Human
Immunogen Region:26-234aa
Immunogen Sequence:AAIGSCSKE YRVLLGQLQK QTDLMQDTSR LLDPYIRIQG LDVPKLREHC RERPGAFPSE ETLRGLGRRG FLQTLNATLG CVLHRLADLE QRLPKAQDLE RSGLNIEDLE KLQMARPNIL GLRNNIYCMA QLLDNSDTAE PTKAGRGASQ PPTPTPASDA FQRKLEGCRF LHGYHRFMHS VGRVFSKWGE SPNRSRRHSP HQALRK
Post Translational Modifications Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.
Function Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Protein Name Oncostatin-M
Osm
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-6788467
Cellular Localisation Secreted
Alternative Protein Names Oncostatin-M protein
Osm protein
OSM protein

Information sourced from Uniprot.org

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