Human OGA protein (Recombinant) (N-His) (STJP006545)

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STJP006545
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human OGA-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: OGA
Gene ID: 10724
Uniprot ID: OGA_HUMAN
Immunogen Region: Ser6-Lys240
Immunogen: Homo sapiens (Human)
Post Translational Modifications Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other.cleavage does not decrease enzyme activity.
Function Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity. Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.
Protein Name Protein O-Glcnacase
Oga
Beta-N-Acetylglucosaminidase
Beta-N-Acetylhexosaminidase
Beta-Hexosaminidase
Meningioma-Expressed Antigen 5
N-Acetyl-Beta-D-Glucosaminidase
N-Acetyl-Beta-Glucosaminidase
Nuclear Cytoplasmic O-Glcnacase And Acetyltransferase
Ncoat
Cellular Localisation Isoform 3: Nucleus
Isoform 1: Cytoplasm
Alternative Protein Names Protein O-Glcnacase protein
Oga protein
Beta-N-Acetylglucosaminidase protein
Beta-N-Acetylhexosaminidase protein
Beta-Hexosaminidase protein
Meningioma-Expressed Antigen 5 protein
N-Acetyl-Beta-D-Glucosaminidase protein
N-Acetyl-Beta-Glucosaminidase protein
Nuclear Cytoplasmic O-Glcnacase And Acetyltransferase protein
Ncoat protein
OGA protein
HEXC protein
KIAA0679 protein
MEA5 protein
MGEA5 protein

Information sourced from Uniprot.org

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