| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human NUP98-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | NUP98 |
| Gene ID: | 4928 |
| Uniprot ID: | NUP98_HUMAN |
| Immunogen Region: | Glu629-Glu894 |
| Immunogen: | Homo sapiens (Human) |
| Function | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body). (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro). |
| Protein Name | Nuclear Pore Complex Protein Nup98-Nup96 Cleaved Into - Nuclear Pore Complex Protein Nup9898 Kda NucleoporinNucleoporin Nup98Nup98 - Nuclear Pore Complex Protein Nup9696 Kda NucleoporinNucleoporin Nup96Nup96 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-141444 P52948-5Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-2467813 P52948-5Reactome: R-HSA-2500257 P52948-5Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-5663220 P52948-5Reactome: R-HSA-6784531Reactome: R-HSA-68877 P52948-5Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9615933 P52948-5Reactome: R-HSA-9648025 P52948-5Reactome: R-HSA-9705671 |
| Cellular Localisation | Nucleus MembranePeripheral Membrane ProteinNucleoplasmic SideNucleusNuclear Pore ComplexNucleoplasmLocalized To The Nucleoplasmic Side Of The Nuclear Pore Complex (Npc)At Or Near The Nucleoplasmic BasketDissociates From The Dissasembled Npc Structure Early During Prophase Of MitosisColocalized With Nup153 And Tpr To The Nuclear Basket Of NpcColocalized With Dhx9 In Diffuse And Discrete Intranuclear Foci (Glfg-Body)(Microbial Infection) Remains Localized To The Nuclear Membrane After Poliovirus (Pv) Infection |
| Alternative Protein Names | Nuclear Pore Complex Protein Nup98-Nup96 Cleaved Into - Nuclear Pore Complex Protein Nup98 protein98 Kda Nucleoporin proteinNucleoporin Nup98 proteinNup98 - Nuclear Pore Complex Protein Nup96 protein96 Kda Nucleoporin proteinNucleoporin Nup96 proteinNup96 proteinNUP98 proteinADAR2 protein |
Information sourced from Uniprot.org
