Human NUDT16L1/SDOS protein (Recombinant) (His-Tag) (STJP017071)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NUDT16L1/SDOS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NUDT16L1 |
| Gene ID | 84309 |
| Uniprot ID | TIRR_HUMAN |
| Accession Number | NP_115725 |
| Immunogen | Human |
| Immunogen Region | 1-211aa |
| Immunogen Sequence |
Additional Info
| Function | Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA. |
| Protein Name | Tudor-Interacting Repair Regulator ProteinNudt16-Like Protein 1Protein Syndesmos |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Tudor-Interacting Repair Regulator Protein proteinNudt16-Like Protein 1 proteinProtein Syndesmos proteinNUDT16L1 proteinSDOS proteinTIRR protein |
Information sourced from Uniprot.org