Human NSFL1C protein (Recombinant) (N-His-SUMO) (STJP007958)

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STJP007958
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NSFL1C-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NSFL1C
Gene ID: 55968
Uniprot ID: NSF1C_HUMAN
Immunogen Region: Ser271-Thr370
Immunogen: Homo sapiens (Human)
Function Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Protein Name Nsfl1 Cofactor P47
Ubx Domain-Containing Protein 2c
P97 Cofactor P47
Database Links Reactome: R-HSA-9013407
Cellular Localisation Nucleus
Golgi Apparatus
Golgi Stack
Chromosome
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Predominantly Nuclear In Interphase Cells
Bound To The Axial Elements Of Sex Chromosomes In Pachytene Spermatocytes
A Small Proportion Of The Protein Is Cytoplasmic
Associated With Golgi Stacks
Localizes To Centrosome During Mitotic Prophase And Metaphase
Alternative Protein Names Nsfl1 Cofactor P47 protein
Ubx Domain-Containing Protein 2c protein
P97 Cofactor P47 protein
NSFL1C protein
UBXN2C protein

Information sourced from Uniprot.org

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