| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human NRG4-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | NRG4 |
| Gene ID: | 145957 |
| Uniprot ID: | NRG4_HUMAN |
| Immunogen Region: | Met1-Phe62 |
| Immunogen: | Homo sapiens (Human) |
| Function | Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. |
| Protein Name | Pro-Neuregulin-4 - Membrane-Bound IsoformPro-Nrg4 Cleaved Into - Neuregulin-4Nrg-4 |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-1236394Reactome: R-HSA-1250196Reactome: R-HSA-1250342Reactome: R-HSA-1250347Reactome: R-HSA-1251985Reactome: R-HSA-1257604Reactome: R-HSA-1963640Reactome: R-HSA-1963642Reactome: R-HSA-2219530Reactome: R-HSA-5673001Reactome: R-HSA-6785631Reactome: R-HSA-6811558Reactome: R-HSA-8847993Reactome: R-HSA-8863795Reactome: R-HSA-9664565Reactome: R-HSA-9665686 |
| Cellular Localisation | Pro-Neuregulin-4Membrane-Bound Isoform: Cell MembraneSingle-Pass Type I Membrane ProteinDoes Not Seem To Be ActiveNeuregulin-4: Secreted |
| Alternative Protein Names | Pro-Neuregulin-4 - Membrane-Bound Isoform proteinPro-Nrg4 Cleaved Into - Neuregulin-4 proteinNrg-4 proteinNRG4 protein |
Information sourced from Uniprot.org