Human NPL protein (Recombinant) (His-Tag) (STJP017164)

Name: Human NPL protein (Recombinant) (His-Tag) (STJP017164)
SKU: STJP017164
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017164

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Short Description	Recombinant-Human NPL-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	NPL
Gene ID	80896
Uniprot ID	NPL_HUMAN
Accession Number	NP_110396
Immunogen	Human
Immunogen Region	1-320aa
Immunogen Sequence	MAFPKKKLQG LVAATITPMT ENGEINFSVI GQYVDYLVKE QGVKNIFVNG TTGEGLSLSV SERRQVAEEW VTKGKDKLDQ VIIHVGALSL KESQELAQHA AEIGADGIAV IAPFFLKPWT KDILINFLKE VAAAAPALPF YYYHIPALTG VKIRAEELLD GILDKIPTFQ GLKFSDTDLL DFGQCVDQNR QQQFAFLFGV DEQLLS

Tissue Specificity	Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.
Function	Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (Probable).
Protein Name	N-Acetylneuraminate Lyase Nalase N-Acetylneuraminate Pyruvate-Lyase N-Acetylneuraminic Acid Aldolase Sialate Lyase Sialate-Pyruvate Lyase Sialic Acid Aldolase Sialic Acid Lyase
Database Links	Reactome: R-HSA-4085001
Cellular Localisation	Cytoplasm
Alternative Protein Names	N-Acetylneuraminate Lyase protein Nalase protein N-Acetylneuraminate Pyruvate-Lyase protein N-Acetylneuraminic Acid Aldolase protein Sialate Lyase protein Sialate-Pyruvate Lyase protein Sialic Acid Aldolase protein Sialic Acid Lyase protein NPL protein C1orf13 protein

Information sourced from Uniprot.org