Human NPC2 (Niemann Pick Disease Type C2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017414)
SPECIFICATIONS
General Information
| Short Description | This NPC2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.31ng/mL |
| Detection Limit | 0.781-50ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | NPC2 |
| Gene ID | 10577 |
| Uniprot ID | NPC2_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Detected in gallbladder bile. Detected in fibroblasts, kidney, liver, spleen, small intestine, placenta and testis (at protein level). Epididymis. |
| Post Translational Modifications | |
| Function | Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport. |
| Protein Name | Npc Intracellular Cholesterol Transporter 2Epididymal Secretory Protein E1Human Epididymis-Specific Protein 1He1Niemann-Pick Disease Type C2 Protein |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8964038 |
| Cellular Localisation | SecretedEndoplasmic ReticulumLysosomeInteraction With Cell-Surface M6pr Mediates Endocytosis And Targeting To Lysosomes |
| Alternative ELISA Names | Npc Intracellular Cholesterol Transporter 2 ELISA kitEpididymal Secretory Protein E1 ELISA kitHuman Epididymis-Specific Protein 1 ELISA kitHe1 ELISA kitNiemann-Pick Disease Type C2 Protein ELISA kitNPC2 ELISA kitHE1 ELISA kit |
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Information sourced from Uniprot.org