| Post Translational Modifications | Highly glycosylated. |
| Function | Plays a major role in cholesterol homeostasis. Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia. May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation. May be involved in caveolin trafficking from the plasma membrane. In addition, acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. |
| Protein Name | Npc1-Like Intracellular Cholesterol Transporter 1Npc1l1Niemann-Pick C1-Like Protein 1 |
| Database Links | Reactome: R-HSA-8963678 Q9UHC9-2 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle MembraneSubfractionation Of Brush Border Membranes From Proximal Enterocytes Suggests Considerable Association With The Apical Membrane FractionExists As A Predominantly Cell Surface Membrane Expressed ProteinLocalizes In A Subcellular Vesicular Compartment Rich In Rab5 |
| Alternative Protein Names | Npc1-Like Intracellular Cholesterol Transporter 1 proteinNpc1l1 proteinNiemann-Pick C1-Like Protein 1 proteinNPC1L1 protein |
Information sourced from Uniprot.org
