| Post Translational Modifications | Isoform 4: N-glycosylated and glycosylation is required for its proper function. Isoform 3: N-glycosylated. |
| Function | NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2. Can also catalyze to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 4: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. Involved in redox signaling in vascular cells. Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Isoform 3: Lacks superoxide-generating NADPH oxidase activity. |
| Protein Name | Nadph Oxidase 4Kidney Oxidase-1Kox-1Kidney Superoxide-Producing Nadph OxidaseRenal Nad(Ph-Oxidase |
| Database Links | Reactome: R-HSA-3299685Reactome: R-HSA-9702518Reactome: R-HSA-9703465 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCell MembraneCell JunctionFocal AdhesionNucleusIsoform 4: NucleusNucleolusCytoplasmPerinuclear RegionIsoform 3: CytoplasmIsoform 5: CytoplasmIsoform 6: Cytoplasm |
| Alternative Protein Names | Nadph Oxidase 4 proteinKidney Oxidase-1 proteinKox-1 proteinKidney Superoxide-Producing Nadph Oxidase proteinRenal Nad(Ph-Oxidase proteinNOX4 proteinRENOX protein |
Information sourced from Uniprot.org
