Human NKX2-1 protein (Recombinant) (N-GST) (STJP004756)

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STJP004756
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NKX2-1-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NKX2-1
Gene ID: 7080
Uniprot ID: NKX21_HUMAN
Immunogen Region: Ala40-Pro111
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on serine residues by STK3/MST2.
Function Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1.
Protein Name Homeobox Protein Nkx-2.1
Homeobox Protein Nk-2 Homolog A
Thyroid Nuclear Factor 1
Thyroid Transcription Factor 1
Ttf-1
Thyroid-Specific Enhancer-Binding Protein
T/Ebp
Cellular Localisation Nucleus
Alternative Protein Names Homeobox Protein Nkx-2.1 protein
Homeobox Protein Nk-2 Homolog A protein
Thyroid Nuclear Factor 1 protein
Thyroid Transcription Factor 1 protein
Ttf-1 protein
Thyroid-Specific Enhancer-Binding Protein protein
T/Ebp protein
NKX2-1 protein
NKX2A protein
TITF1 protein
TTF1 protein

Information sourced from Uniprot.org

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