| Tissue Specificity | Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, and pancreas. Within peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes. |
| Post Translational Modifications | Phosphorylated on Tyr-7.this phosphorylation is required for NKp80/KLRF1-mediated cytotoxicity. |
| Function | Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases. |
| Protein Name | Killer Cell Lectin-Like Receptor Subfamily F Member 1Lectin-Like Receptor F1Activating Coreceptor Nkp80C-Type Lectin Domain Family 5 Member C |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Killer Cell Lectin-Like Receptor Subfamily F Member 1 proteinLectin-Like Receptor F1 proteinActivating Coreceptor Nkp80 proteinC-Type Lectin Domain Family 5 Member C proteinKLRF1 proteinCLEC5C proteinML protein |
Information sourced from Uniprot.org
