| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human NKp30-Fc-Tag protein was developed from and has a target region of Fc-Tag. For use in research applications. |
| Conjugation: | Unconjugated |
| Gene Symbol: | NCR3 |
| Gene ID: | 259197 |
| Uniprot ID: | NCTR3_HUMAN |
| Function | Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
| Protein Name | Natural Cytotoxicity Triggering Receptor 3 Activating Natural Killer Receptor P30 Natural Killer Cell P30-Related Protein Nk-P30 Nkp30 Cd Antigen Cd337 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Protein Names | Natural Cytotoxicity Triggering Receptor 3 protein Activating Natural Killer Receptor P30 protein Natural Killer Cell P30-Related Protein protein Nk-P30 protein Nkp30 protein Cd Antigen Cd337 protein NCR3 protein 1C7 protein LY117 protein |
Information sourced from Uniprot.org