SDS-PAGE of recombinant human NKIRAS2 protein under reducing conditions stained with Coomassie blue

Human NKIRAS2 protein (Recombinant) (His-Tag) (STJP017632)

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STJP017632
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Short Description :Recombinant-Human NKIRAS2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 0.1M NaCl
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:NKIRAS2
Gene ID:28511
Uniprot ID:KBRS2_HUMAN
Accession Number:NP_001138399
Immunogen:Human
Immunogen Region:1-191aa
Immunogen Sequence:MGKSCK VVVCGQASVG KTSILEQLLY GNHVVGSEMI ETQEDIYVGS IETDRGVREQ VRFYDTRGLR DGAELPRHCF SCTDGYVLVY STDSRESFQR VELLKKEIDK SKDKKEVTIV VLGNKCDLQE QRRVDPDVAQ HWAKSEKVKL WEVSVADRRS LLEPFVYLAS KMTQPQSKSA FPLSRKNKGS GSLDG
Tissue Specificity Widely expressed.
Function Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Protein Name Nf-Kappa-B Inhibitor-Interacting Ras-Like Protein 2
I-Kappa-B-Interacting Ras-Like Protein 2
Kappa B-Ras Protein 2
Kappab-Ras2
Database Links Reactome: R-HSA-1810476
Reactome: R-HSA-445989
Reactome: R-HSA-933542
Cellular Localisation Cytoplasm
Alternative Protein Names Nf-Kappa-B Inhibitor-Interacting Ras-Like Protein 2 protein
I-Kappa-B-Interacting Ras-Like Protein 2 protein
Kappa B-Ras Protein 2 protein
Kappab-Ras2 protein
NKIRAS2 protein
KBRAS2 protein

Information sourced from Uniprot.org

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