| Function | Regulates cytotoxic granule exocytosis in effector lymphocytes, thus acting as a critical mediator of inflammation in a broad range of infectious and non-infectious diseases. Essential for cytotoxic degranulation of natural killer (NK) cells and CD8(+) T-cells and for the activation of CD4(+) T-cells following infection. Plays a critical role in CD8(+) T-cell and NK cell-mediated cytolysis of target cells and contributes to the cytolytic activity via the perforin/granzyme pathway by enhancing exocytosis of LAMP1-carrying lytic granules. Contributes to NK cell-mediated control of cancer metastasis. |
| Protein Name | Protein Nkg7G-Csf-Induced Gene 1 ProteinGig-1 ProteinGranule Membrane Protein Of 17 KdaGmp-17Natural Killer Cell Protein 7P15-Tia-1 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytolytic Granule Membrane |
| Alternative Protein Names | Protein Nkg7 proteinG-Csf-Induced Gene 1 Protein proteinGig-1 Protein proteinGranule Membrane Protein Of 17 Kda proteinGmp-17 proteinNatural Killer Cell Protein 7 proteinP15-Tia-1 proteinNKG7 proteinGIG1 protein |
Information sourced from Uniprot.org