Human NKG2D ligand 2/ULBP2 protein (Recombinant) (C-hFc&His) (STJP001036)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human NKG2D ligand 2/ULBP2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly26-Ser217) of human ULBP2 (Accession #NP_079493.1) fused with an Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human NKG2D ligand 2/ULBP2-C-hFc&His protein was developed in hek293 cells using the region Gly26-Ser217. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Human ULBP2 Protein at 2 Mu g/mL (100 Mu L/well) can bind NKG2D-raFc with a linear range of 1.95-336.7ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | ULBP2 |
| Gene ID | 80328 |
| Uniprot ID | ULBP2_HUMAN |
| Immunogen | Recombinant Human NKG2D ligand 2/ULBP2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly26-Ser217) of human ULBP2 (Accession #NP_079493.1) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Gly26-Ser217 |
| Immunogen Sequence | GRADPHSLCYDITVIPKFRP GPRWCAVQGQVDEKTFLHYD CGNKTVTPVSPLGKKLNVTT AWKAQNPVLREVVDILTEQL RDIQLENYTPKEPLTLQARM SCEQKAEGHSSGSWQFSFDG QIFLLFDSEKRMWTTVHPGA RKMKEKWENDKVVAMSFHYF SMGDCIGWLEDFLMGMDSTL EPSAGAPLAMSS |
Additional Info
| Tissue Specificity | Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. |
| Function | Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. |
| Protein Name | Ul16-Binding Protein 2Alcan-AlphaNkg2d Ligand 2N2dl-2Nkg2dl2Retinoic Acid Early Transcript 1h |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorEndoplasmic ReticulumSecretedIn Cmv-Infected FibroblastsDetected In The Endoplasmic Reticulum/Cis-Golgi |
| Alternative Protein Names | Ul16-Binding Protein 2 proteinAlcan-Alpha proteinNkg2d Ligand 2 proteinN2dl-2 proteinNkg2dl2 proteinRetinoic Acid Early Transcript 1h proteinULBP2 proteinN2DL2 proteinRAET1H proteinUNQ463 proteinPRO791 protein |
Information sourced from Uniprot.org