Biotinylated Human NKG2D on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Human NKG2D/CD314 protein (Recombinant) (N-His-Avi) {Biotin} (STJP001575)

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STJP001575
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NKG2D/CD314-N-His-Avi protein was developed from hek293 and has a target region of N-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: KLRK1
Gene ID: 100528032/22914
Uniprot ID: NKG2D_HUMAN
Immunogen Region: Phe78-Val216
Immunogen: DNA sequence encoding Human NKG2D/CD314 including a N-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Protein Name Nkg2-D Type Ii Integral Membrane Protein
Killer Cell Lectin-Like Receptor Subfamily K Member 1
Nk Cell Receptor D
Nkg2-D-Activating Nk Receptor
Cd Antigen Cd314
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-2172127
Reactome: R-HSA-2424491
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Colocalized With Hcst On The Cell Surface
Alternative Protein Names Nkg2-D Type Ii Integral Membrane Protein protein
Killer Cell Lectin-Like Receptor Subfamily K Member 1 protein
Nk Cell Receptor D protein
Nkg2-D-Activating Nk Receptor protein
Cd Antigen Cd314 protein
KLRK1 protein
D12S2489E protein
NKG2D protein

Information sourced from Uniprot.org

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