Biotinylated Human NKG2D on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Human NKG2D/CD314 protein (Recombinant) (N-His-Avi) {Biotin} (STJP001575)

SKU:
STJP001575
$787.29 - $2,432.25
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Short Description :Recombinant-Human NKG2D/CD314-N-His-Avi protein was developed from hek293 and has a target region of N-His-Avi. For use in research applications.
Host:HEK293
Note:STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Biotin
Dilution Range:Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Formulation:Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Storage Instruction:The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol:KLRK1
Gene ID:22914
Uniprot ID:NKG2D_HUMAN
Immunogen:DNA sequence encoding Human NKG2D/CD314 including a N-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Immunogen Region:Phe78-Val216
Function Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Protein Name Nkg2-D Type Ii Integral Membrane Protein
Killer Cell Lectin-Like Receptor Subfamily K Member 1
Nk Cell Receptor D
Nkg2-D-Activating Nk Receptor
Cd Antigen Cd314
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-2172127
Reactome: R-HSA-2424491
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Colocalized With Hcst On The Cell Surface
Alternative Protein Names Nkg2-D Type Ii Integral Membrane Protein protein
Killer Cell Lectin-Like Receptor Subfamily K Member 1 protein
Nk Cell Receptor D protein
Nkg2-D-Activating Nk Receptor protein
Cd Antigen Cd314 protein
KLRK1 protein
D12S2489E protein
NKG2D protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP013272 Human CD314/KLRK1/NKG2D protein (Recombinant) (N-His) (STJP013272) Mammalian Cells ELISA/WB
STJP020199 Human NKG-2D/KLRK1/CD314 protein (Recombinant) (N-His&Avi) {Biotin} (STJP020199) HEK293 cells
STJP013889 Mouse CD314/KLRK1/NKG2D protein (Recombinant) (N-His) (STJP013889) Mammalian Cells ELISA/WB
STJP009555 Mouse CD314/KLRK1/NKG2D protein (Recombinant) (N-His) (STJP009555) E.coli ELISA/Immunogen/SDS-PAGE/WB
STJP014134 Cynomolgus monkey CD314/KLRK1/NKG2D protein (Recombinant) (N-His) (STJP014134) Mammalian Cells ELISA/WB

Related Products

!