| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human NKG2C&CD94-N-His-Avi protein was developed from hek293 and has a target region of N-His-Avi. For use in research applications. |
| Conjugation: | Biotin |
| Formulation: | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Dilution Range: | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Storage Instruction: | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). |
| Gene Symbol: | KLRC2 |
| Gene ID: | 3822 |
| Uniprot ID: | NKG2C_HUMAN |
| Immunogen Region: | Glu98-Leu231 (NKG2C) & Ser34-Ile179 (CD94) |
| Immunogen: | DNA sequence encoding Human NKG2C&CD94 including a N-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Function | Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation. |
| Protein Name | Nkg2-C Type Ii Integral Membrane Protein Cd159 Antigen-Like Family Member C Nk Cell Receptor C Nkg2-C-Activating Nk Receptor Cd Antigen Cd159c |
| Database Links | Reactome: R-HSA-2172127 Reactome: R-HSA-2424491 |
| Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Nkg2-C Type Ii Integral Membrane Protein protein Cd159 Antigen-Like Family Member C protein Nk Cell Receptor C protein Nkg2-C-Activating Nk Receptor protein Cd Antigen Cd159c protein KLRC2 protein NKG2C protein |
Information sourced from Uniprot.org