Tissue Specificity | Kidney.localizes to the thick ascending limbs (at protein level). |
Post Translational Modifications | Phosphorylated at Ser-91, Thr-100 and Thr-105 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), promoting its activity. |
Function | Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. |
Protein Name | Solute Carrier Family 12 Member 1Bumetanide-Sensitive Sodium-(Potassium-Chloride Cotransporter 1Bsc1Kidney-Specific Na-K-Cl SymporterNa-K-2cl Cotransporter 2Nkcc2 |
Database Links | Reactome: R-HSA-426117Reactome: R-HSA-5619104 |
Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
Alternative ELISA Names | Solute Carrier Family 12 Member 1 ELISA kitBumetanide-Sensitive Sodium-(Potassium-Chloride Cotransporter 1 ELISA kitBsc1 ELISA kitKidney-Specific Na-K-Cl Symporter ELISA kitNa-K-2cl Cotransporter 2 ELISA kitNkcc2 ELISA kitSLC12A1 ELISA kitNKCC2 ELISA kit |
output | |
Information sourced from Uniprot.org