Human NKAT-2/KIR2DL3/CD158b2 protein (Recombinant) (C-hFc&His) (STJP001044)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human NKAT-2/KIR2DL3/CD158b2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (His22-His245) of human KIR2DL3/CD158b2 (Accession #NP_056952.2) fused with an Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human NKAT-2/KIR2DL3/CD158b2-C-hFc&His protein was developed in hek293 cells using the region His22-His245. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA.Immobilized Human KIR2DL3 at 1 Mu g/mL (100 Mu L/well) can bind KIR2DL3 Rabbit pAb with a linear range of 2-54 ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | KIR2DL3 |
| Gene ID | 3804 |
| Uniprot ID | KI2L3_HUMAN |
| Immunogen | Recombinant Human NKAT-2/KIR2DL3/CD158b2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (His22-His245) of human KIR2DL3/CD158b2 (Accession #NP_056952.2) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Region | His22-His245 |
| Immunogen Sequence | HEGVHRKPSLLAHPGPLVKS EETVILQCWSDVRFQHFLLH REGKFKDTLHLIGEHHDGVS KANFSIGPMMQDLAGTYRCY GSVTHSPYQLSAPSDPLDIV ITGLYEKPSLSAQPGPTVLA GESVTLSCSSRSSYDMYHLS REGEAHERRFSAGPKVNGTF QADFPLGPATHGGTYRCFGS FRDSPYEWSNSSDPLLVSVT GNPSNSWLSPTEPSSETGNP RHLH |
Additional Info
| Function | Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis. |
| Protein Name | Killer Cell Immunoglobulin-Like Receptor 2dl3Cd158 Antigen-Like Family Member B2Kir-023gbKiller Inhibitory Receptor Cl 2-3Nkat2aNkat2bNatural Killer-Associated Transcript 2Nkat-2P58 Natural Killer Cell Receptor Clone Cl-6P58 Nk Receptor Cl-6P58.2 Mhc Class-I-Specific Nk ReceptorCd Antigen Cd158b2 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Killer Cell Immunoglobulin-Like Receptor 2dl3 proteinCd158 Antigen-Like Family Member B2 proteinKir-023gb proteinKiller Inhibitory Receptor Cl 2-3 proteinNkat2a proteinNkat2b proteinNatural Killer-Associated Transcript 2 proteinNkat-2 proteinP58 Natural Killer Cell Receptor Clone Cl-6 proteinP58 Nk Receptor Cl-6 proteinP58.2 Mhc Class-I-Specific Nk Receptor proteinCd Antigen Cd158b2 proteinKIR2DL3 proteinCD158B2 proteinKIRCL23 proteinNKAT2 protein |
Information sourced from Uniprot.org