| Function | Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells. Inhibits lamellipodia formation, when overexpressed. Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures. |
| Protein Name | NischarinImidazoline Receptor 1I-1Ir1Imidazoline Receptor Antisera-Selected ProteinHirasImidazoline-1 ReceptorI1rImidazoline-1 Receptor Candidate ProteinI-1 Receptor Candidate ProteinI1r Candidate Protein |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9696264Reactome: R-HSA-9696270 |
| Cellular Localisation | Cell MembraneCytoplasmEarly EndosomeRecycling EndosomeEnriched In The Early/Sorting And Recycling EndosomesColocalized In Early/Sorting Endosomes With Eea1 And Snx2 And In Recycling Endosomes With Transferrin ReceptorDetected In The Perinuclear Region Partially Associated With Punctate StructuresColocalizes With Pak1 In CytoplasmVesicular Structures In The Perinuclear Area And Membrane RufflesColocalizes With Rac1 In The Cytoplasm And Vesicles StructuresColocalized With Mapk1 And Mapk3 In Rvlm Neurons |
| Alternative Protein Names | Nischarin proteinImidazoline Receptor 1 proteinI-1 proteinIr1 proteinImidazoline Receptor Antisera-Selected Protein proteinHiras proteinImidazoline-1 Receptor proteinI1r proteinImidazoline-1 Receptor Candidate Protein proteinI-1 Receptor Candidate Protein proteinI1r Candidate Protein proteinNISCH proteinIRAS proteinKIAA0975 protein |
Information sourced from Uniprot.org
