Human NHP2 protein (Recombinant) (N-His) (STJP014820)

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STJP014820-100
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Host: E.coli
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NHP2-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 100mM NaCl, 1mM DTT, pH 8.0.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: NHP2
Gene ID: 55651
Uniprot ID: NHP2_HUMAN
Immunogen Region: Met1-Leu153
Immunogen: Homo sapiens (Human)
Function Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Protein Name H/Aca Ribonucleoprotein Complex Subunit 2
Nucleolar Protein Family A Member 2
Snornp Protein Nhp2
Database Links Reactome: R-HSA-171319
Reactome: R-HSA-6790901
Cellular Localisation Nucleus
Nucleolus
Cajal Body
Also Localized To Cajal Bodies (Coiled Bodies)
Alternative Protein Names H/Aca Ribonucleoprotein Complex Subunit 2 protein
Nucleolar Protein Family A Member 2 protein
Snornp Protein Nhp2 protein
NHP2 protein
NOLA2 protein
HSPC286 protein

Information sourced from Uniprot.org

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