| Post Translational Modifications | Phosphorylated on serine residues. In undifferentiated erythrocytes, phosphorylated by MAPK8 which then leads to ubiquitination and protein degradation. Sumoylated. Sumoylation is required for translocation to nuclear bodies PODs, anchoring to the gene loci, and transactivation of the beta-globin gene. Ubiquitinated mainly by 'Lys63'-linked ubiquitin. Polyubiquitination with 'Lys63'-linked ubiquitin by ITCH retains NFE2 in the cytoplasm preventing its transactivation activity. In undifferentiated erythrocyte, ubiquitinated after MAPK8-mediatd phosphorylation leading to protein degradation. |
| Function | Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. |
| Protein Name | Transcription Factor Nf-E2 45 Kda SubunitLeucine Zipper Protein Nf-E2Nuclear Factor - Erythroid-Derived 2 45 Kda SubunitP45 Nf-E2 |
| Database Links | Reactome: R-HSA-8936459Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusPml BodyCytoplasmThe Sumoylated Form Locates To The Nuclear Bodies Pml Oncogenic Domains (Pods)Translocated To The Cytoplasm Through Interaction With Itch |
| Alternative Protein Names | Transcription Factor Nf-E2 45 Kda Subunit proteinLeucine Zipper Protein Nf-E2 proteinNuclear Factor - Erythroid-Derived 2 45 Kda Subunit proteinP45 Nf-E2 proteinNFE2 protein |
Information sourced from Uniprot.org
